Regenerative
Regenerative news and research from Life and Health Today, updated daily.
- Longer ureteral stents in children tied to higher infection risk despite antibiotics
More than a quarter of children with internal kidney-drainage tubes developed urinary tract infections even while taking daily preventive antibiotics, a study in the Journal of Pediatric Urology...
- Gene therapy for a fatal infant muscle disease showed no liver toxicity in animal studies
A gene therapy being tested in boys with X-linked myotubular myopathy, a severe muscle disease that often kills in infancy, produced no signs of liver damage in monkeys or dogs in preclinical...
- Personalized mRNA cancer vaccine cuts melanoma recurrence risk by 42% in 1,137-person trial
A bespoke vaccine built from each patient's own tumor mutations, combined with an immunotherapy drug, reduced the chance of skin cancer returning or the patient dying by 42% compared with the...
- One child, 80 months on: gene therapy holds off a fatal brain disease
A single patient treated at 30 months of age with an experimental stem cell gene therapy for Mucopolysaccharidosis IIIA, a rare inherited disease that kills children in their late teens, showed...
- Hip osteoarthritis reshapes bone marrow immune cells, lab study finds
Researchers publishing in GeroScience found that elderly patients with hip osteoarthritis have a higher proportion of immature immune cells in their bone marrow than patients who had suffered a...
- Sickle cell trait shapes which malaria parasites can infect you, study finds
A study of more than 2,000 schoolchildren in Cameroon found that people carrying one copy of the sickle cell gene are infected by a genetically distinct variety of malaria parasites compared with...
- Antibody blocks bone growth in soft tissue in FOP mouse study
Researchers have identified a signalling protein called CCN2 as a key driver of the runaway bone formation seen in fibrodysplasia ossificans progressiva, a rare and disabling genetic disorder. In...
- FDA approves pritelivir for drug-resistant herpes lesions in immunocompromised patients
The US Food and Drug Administration has approved a new oral drug, pritelivir, for herpes simplex virus lesions that have stopped responding to existing treatments. The approval covers a specific...
- A receptor linked to vascular ageing may be targetable without shutting down immunity
A review published in Aging Cell argues that a protein called TLR4, long known for its role in immune defence, also drives the ageing of blood vessel walls. Broad attempts to block it have failed...
- Quercetin blocks a clot-worsening protein in mice with deep vein thrombosis
A study published in the European Heart Journal found that a protein called syndecan-4 plays a role in worsening deep vein thrombosis, and that quercetin, a compound found in many plants, reduced...
- Blood exosomes may keep shingles pain alive after the virus is gone
Researchers at the University of Colorado Anschutz found that tiny molecular packages circulating in the blood of people with long-term shingles pain can trigger nerve damage in healthy cells in a...
- The strongest peptide binder is not always the best drug candidate
Drug hunters have long optimised peptides, short chains of amino acids used as potential medicines, for how tightly they grip a target protein. A commentary in Genetic Engineering and...
- Mouse study links autism blood-vessel defect to a receptor that can be switched on
Researchers at The Ottawa Hospital and the University of Ottawa found that endothelial cells lining brain blood vessels in a genetic mouse model of autism carry half the normal level of a key...
- Fat cell study finds insulin receptor patterns differ by body location
A laboratory study published in the journal Obesity (Silver Spring, Md.) found that stem cells taken from subcutaneous fat (just under the skin) and visceral fat (around the organs) behave...
- A muscle-support cell's death triggers inflammation and rapid atrophy in mice
Researchers found that wiping out a population of connective-tissue cells called fibro-adipogenic progenitors caused mice to lose 30% of their lean mass, driven by a surge in inflammatory...
- A UTI drug may work in a second way: helping bladder cells destroy hidden bacteria
E. coli can burrow inside the cells lining the bladder and hide from antibiotics, which is one reason urinary tract infections keep coming back. A study published in PLOS Pathogens now reports...
- CRISPR tool maps unknown genes across bacteriophage genomes
Researchers at the University of Otago in New Zealand have built a method that systematically disrupts genes across phage genomes, revealing which ones are essential and which can be replaced or...
- FDA flags Class I recall of CooperSurgical infant nasal CPAP sets over loose tubing
CooperSurgical has recalled specific lots of its INCA Neonatal Nasal CPAP Complete Set and Replacement Set after the company found that tubing can disconnect from the nasal cannula, potentially...
- CRISPR therapy cuts sickle haemoglobin by two-thirds in lab and mouse tests
Researchers have published preclinical data for CRISPR_SCD001, a gene-editing therapy designed to correct the mutation that causes sickle cell disease. In laboratory cultures and in mice, the...
- Johns Hopkins built a microscope that watches mouse brains for 24 hours straight
A miniaturised, cloud-connected microscope called CloudScope can image a living mouse's brain continuously for more than a day, capturing seizures, tumour cell behaviour and blood-flow changes...
- Lab-built bone marrow chip shows how antibody cells settle and survive
Scientists at Georgia Tech and Vanderbilt University have built a device that reproduces two distinct zones of human bone marrow outside the body, letting them watch antibody-producing cells...
All articles Longevity Performance Biohacking Mental Health RSS